Introducing NES/T
A topical gel for reversible male contraception.
How NES/T Works
1
Apply once a day
On the shoulders and upper arms – morning or night. The pump delivers the same amount every time and it dries fast, so it fits easily into your routine.
2
Two FDA-approved hormones, one purpose
NES/T combines two hormones that work together. One temporarily pauses sperm production. The other maintains normal testosterone levels to support energy, mood, and sex drive. Designed for no trade-offs.
3
Reliable and reversible
Trials have shown that men reach contraceptive levels within a couple months of use. When you stop, sperm counts restore to fertile levels.
NES/T Gel completed a Phase 2b trial across 17 sites with 462 couples enrolled.
Phase three trials are anticipated to begin in 2026.
Phase three trials are anticipated to begin in 2026.
"I've only experienced increased libido. Maybe I'm just lucking out but I hope this is the case for the majority of participants. If it is, it's definitely going to change contraception as a whole."
Matthew Treviño & Emily Fletcher
Phase 2b Trial Participants
Publications
Select research on NES/T and hormonal male contraception.
2025
Contraline Licenses NES/T
Contraline, Inc. · Press Release
2025
Development of a transdermal gel for reversible male contraception
Regine Sitruk-Ware, Diana L. Blithe, Stephanie T. Page, Christina Wang · Contraception
2019
Combined nestorone–testosterone gel suppresses serum gonadotropins to concentrations associated with effective hormonal contraception in men
B. D. Anawalt, M. Y. Roth, J. Ceponis, V. Surampudi, J. K. Amory, R. S. Swerdloff, P. Y. Liu, C. Dart, W. J. Bremner, R. Sitruk-Ware, N. Kumar, D. L. Blithe, S. T. Page, C. Wang · Andrology
Effective, reversible contraception — on your terms.
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Contraline’s products are investigational and have not been approved by the U.S. Food and Drug Administration (FDA) or any other regulatory authority.